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Efficiency. The efficacy and safety of Purchase Viagra For Bitcoin Online Pharmacy were evaluated in 21 randomized double-blind placebo-controlled studies lasting up to 6 months in 3000 patients from 19 to 87 years with erectile dysfunction of different etiology (organic, psychogenic or mixed). The efficacy of the drug was evaluated globally using an erection diary, an international erectile function index (validated questionnaire on the state of sexual function) and a partner survey.

The effectiveness of Purchase Viagra For Bitcoin Online Pharmacy, defined as the ability to achieve and maintain an erection sufficient for satisfactory sexual intercourse, has been demonstrated in all studies and confirmed in long-term studies lasting 1 year. In studies with the use of fixed-dose proportion of patients reporting that treatment improved their erections were 62% (dose of Buy Sildenafil Bitcoin 25 mg), 74% (dose Buy Viagra With Bitcoins 50 mg) and 82% (dose Generic Female Viagra For Bitcoin 100 mg) compared to 25% in the placebo group. Analysis of the international index of erectile function showed that in addition to improving erection treatment Purchase Viagra For Bitcoin Online Pharmacy also increased the quality of orgasm, allowing to achieve satisfaction from sexual intercourse and overall satisfaction.

According to the generalized data, 59% of patients with diabetes, 43% of patients who underwent radical prostatectomy and 83% of patients with spinal cord injuries (against 16, 15 and 12% in the placebo group, respectively) were reported to have improved erection in the treatment of Purchase Viagra For Bitcoin Online Pharmacy.

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Suction. After intake of Discount Red Viagra With Bitcoin is rapidly absorbed. Absolute bioavailability averages about 40% (25 to 63%). In vitro Purchase Viagra For Bitcoin Online Pharmacy at a concentration of about 1.7 ng/ml (3.5 nm) inhibits the activity of PDE-5 50%. After a single dose of Kamagra For Bitcoin 100 mg average Cmax free Cheap Viagra Professional Accept Bitcoin in plasma men is about 18 ng/ml (38 nm). Cmax when taking Buy Viagra With Bitcoin inside fasting is achieved for an average of 60 minutes (from 30 to 120 minutes). When taken in combination with fatty foods, the rate of absorption decreases: Cmax decreases by an average of 29%, and Tmax increases by 60 minutes, but the degree of absorption does not change significantly (AUC decreases by 11%).

Distribution. The average Vss of Purchase Viagra For Bitcoin Online Pharmacy is 105 l. the Association of Purchase Viagra For Bitcoin Online Pharmacy and its main circulating N-demethyl metabolite with plasma proteins is about 96% and does not depend on the total concentration of the drug. Less than 0.0002% of the dose of Purchase Viagra For Bitcoin Online Pharmacy (an average of 188 ng) was found in sperm 90 minutes after taking the drug.

Metabolism. Purchase Viagra For Bitcoin Online Pharmacy is metabolized mainly in the liver by the action of CYP3A4 isoenzyme (main pathway) and CYP2C9 isoenzyme (minor pathway). The main circulating active metabolite, formed as a result of N-demethylation of Purchase Viagra For Bitcoin Online Pharmacy, undergoes further metabolism. The selectivity of this metabolite against PDE is comparable to that of Purchase Viagra For Bitcoin Online Pharmacy, and its activity against PDE-5 in vitro is about 50% of the activity of Purchase Viagra For Bitcoin Online Pharmacy. The concentration of the metabolite in the blood plasma of healthy volunteers was about 40% of the concentration of Purchase Viagra For Bitcoin Online Pharmacy. N-demethyl metabolite undergoes further metabolism; its T1/2 is about 4 no.

Breeding. The total clearance of Purchase Viagra For Bitcoin Online Pharmacy is 41 l/h, and the final T1/2 — 3-5 h. After oral administration, as well as after I/V, Purchase Viagra For Bitcoin Online Pharmacy is excreted as metabolites, mainly by the intestine (about 80% oral dose) and to a lesser extent by the kidneys (about 13% oral dose).

Visual impairment

In rare cases, during post-approval use of all of the inhibitors of PDE5, including Buy Kamagra With Bitcoin, reported NESN is a rare disease and the cause of the decrease or loss of vision. Most of these patients had risk factors, such as decreased ratios of excavation diameter to optic disc (stagnant disc), age over 50, diabetes, hypertension, CHD, hyperlipidemia, and Smoking. In an observational study evaluated whether recent use of drugs class of inhibitors PDE-5 with an acute onset NESN. The results indicate approximately a 2-fold increase in risk NESN within 5T1/2 after application of the PDE-5 inhibitor. According to published literature, the annual incidence of npins IS 2.5–11.8 cases per 100,000 men aged ≥50 years in the General population. Patients should be advised to stop Purchase Viagra For Bitcoin Online Pharmacy therapy in case of sudden loss of vision and consult a doctor immediately.

Persons who have already had a case NESN have an increased risk of relapse NESN. Therefore, the doctor should discuss this risk with such patients, as well as the potential chance of adverse effects of PDE-5 inhibitors. PDE-5 inhibitors, including Purchase Viagra For Bitcoin Online Pharmacy, in such patients should be used with caution and only in situations where the expected benefit outweighs the risk. In patients with episodes of development PINZN with loss of vision in one eye receiving Buy Kamagra Bitcoin is contraindicated (see "Contraindications").

A small number of patients with hereditary retinitis pigmentosa have genetically determined disorders of the PDE of the retina. Information about the safety of the drug Purchase Viagra For Bitcoin Online Pharmacy in patients with retinitis pigmentosa absent, so these patients should not be used Purchase Viagra For Bitcoin Online Pharmacy (see "Contraindications").

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